Anaemia of Chronic Disease Dr. Nadeem Ikram* and Prof. Khalid Hassan** *Department of Pathology, Rawalpindi Medical College,Rawalpindi ** Department of Pathology, Islamabad Medical and Dental College, Islamabad
Anaemia of chronic disease (ACD) is the second most prevalent after anaemia by iron deficiency.
Unfortunately, it is commonly under diagnosed by the clinician and frequently misunderstood and treated
inappropriately. Significant gaps remain in comprehension of the true prevalence or consequences of ACD.
Different diseases are found to be associated with ACD (Table1). It is characterized by inadequate erythrocyte production in the setting of low serum iron, low iron binding capacity, low transferrin, but normal or high serum ferritin with a preserved or even increased macrophage iron stores in the bone marrow. The erythrocytes are usually normocytic and normochromic, but long standing anaemia can give rise to
microcytic and hypochromic blood picture . 1-3.